Why the study?
Does local periarticular injection of an adenovirus encoding viral IL-10 suppress the development of collagen-induced arthritis in mice?
Population
Mice with collagen type II-induced arthritis
Design
Preclinical
Authors
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Local vIL-10 gene delivery may confer systemic protection in murine arthritis models; leaves open translation to human therapy.
Does local periarticular injection of an adenovirus encoding viral IL-10 suppress the development of collagen-induced arthritis in mice?
Local gene delivery of viral IL-10 to a single joint provides systemic protection against collagen-induced arthritis in mice without detectable systemic viral IL-10 levels.
Whalen et al. (1999) studied this question.
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