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May 16, 2006Arthritis Research & TherapyOpen Access

Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis

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Why the study?

Does intra-articular gene transfer of hIL-10, vIL-10, or mut.hIL-10 improve disease pathology in a rabbit model of antigen-induced arthritis?

Population

Female New Zealand White rabbits, weighing approximately 5 to 6 lbs, with antigen-induced arthritis in the…

Comparison

Intra-articular injection of 5 × 10^9 particles… vs Intra-articular injection of adenovirus…

Design

Preclinical

Follow-up

7 days

Authors

AKAnnahita KeravalaConsejo de Ciencia y Tecnología del Estado de TabascoELEric R. LechmanUniversity of PittsburghJNJoan NashUniversity of Pittsburgh

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Implication

May guide preclinical IL-10 gene therapy development; leaves open translation to human arthritis.

Structured PICO

Does intra-articular gene transfer of hIL-10, vIL-10, or mut.hIL-10 improve disease pathology in a rabbit model of antigen-induced arthritis?

P
Population
Female New Zealand White rabbits, weighing approximately 5 to 6 lbs, with antigen-induced arthritis (AIA) in the knee joints.
I
Intervention
Intra-articular injection of 5 × 10^9 particles of replication-defective adenovirus encoding human IL-10 (Ad.hIL-10), viral IL-10 (Ad.vIL-10), or mutant human IL-10 (Ad.mut.hIL-10).
C
Comparator
Intra-articular injection of adenovirus expressing enhanced green fluorescent protein (Ad.eGFP) as an inflamed control, and naïve rabbit knees.
O
Outcome
Joint inflammation (leukocytic infiltration in lavage fluid) and cartilage matrix metabolism (glycosaminoglycan release and synthesis) at days 3 and 7.surrogate

Local adenovirus-mediated gene transfer of human, viral, or mutant human IL-10 are equally effective in ameliorating disease pathology in a rabbit model of antigen-induced arthritis.

Cite This Study

Keravala et al. (2006) studied this question.

synapsesocial.com/papers/6a779f5df6749a0058ec6998https://doi.org/10.1186/ar1960
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Direct Adenoviral Gene Transfer of Viral IL-10 to Rabbit Knees with Experimental Arthritis Ameliorates Disease in Both Injected and Contralateral Control Knees1999 · 144 citations
  2. 2Clinical Trials in the Gene Therapy of Arthritis2000 · 83 citations
  3. 3Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases1992 · 338 citations
  4. 4Immune modulation of collagen‐induced arthritis by intranasal cytokine gene delivery: A model for the therapy of rheumatoid arthritis2005 · 18 citations