Why the study?
Does levosimendan compared to prostaglandin E1 facilitate uptitration of beta-blockers and improve clinical outcomes in patients with advanced chronic heart failure?
Population
75 advanced CHF patients intolerant to beta-blocker uptitration to target doses
Comparison
Monthly 24 h infusion with levosimendan for 3… vs Chronic infusion with prostaglandin E1 for 3…
Design
RCT, randomised
Follow-up
1 year
Authors
Loading...
PGE1 may be preferred over levosimendan in advanced HF; this RCT extends comparative evidence on inotrope choice for beta-blocker uptitration.
Does levosimendan compared to prostaglandin E1 facilitate uptitration of beta-blockers and improve clinical outcomes in patients with advanced chronic heart failure?
Prostaglandin E1 was superior to levosimendan in facilitating beta-blocker uptitration and reducing adverse clinical events in patients with advanced, refractory heart failure.
Berger et al. (2006) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: