Key result
Aspirin did not significantly affect systolic blood pressure (MD -0.78) or diastolic blood pressure (MD -0.86) compared to placebo or no treatment in patients with hypertension.
Why the study?
Aspirin is widely used for secondary prevention in hypertension, but reliable evidence on whether taking aspirin affects blood pressure was lacking.
Does aspirin affect blood pressure in patients with hypertension?
Meta-Analysis (n=20,312)
Does aspirin affect blood pressure in patients with hypertension?
Mean Difference: -0.78 (95% CI -2.41–0.84)
Aspirin use does not significantly affect systolic or diastolic blood pressure in patients with hypertension.
Aspirin does not affect BP in hypertensive patients; confirms neutral hemodynamic profile for secondary prevention.
INTRODUCTION: Aspirin is widely used for secondary prevention in patients with hypertension. However, previous studies mainly focused on the preventive effects of aspirin, and there has been a lack of reliable evidence on whether taking aspirin affects blood pressure This study aimed to investigate whether aspirin would affect the blood pressure in patients with hypertension. METHODS: PubMed, Cochrane database, Embase, Scopus and Medline databases were searched until September 2023. For continuous variables (e.g., blood pressure reduction), the mean difference (MD) was selected as the effect magnitude indices. We used the Cochrane Collaboration's Risk of Bias tool to assess the risk of bias. RESULT: A total of five studies were included, comprising 20,312 patients. We found that aspirin did not affect SBP (MD = -0.78, 95% CI: - 2.41, 0.84). A similar result was found for DBP (MD = -0.86, 95% CI: - 2.14, 0.42). CONCLUSION: This study showed no significant difference in blood pressure between the aspirin and control groups, suggesting that aspirin does not affect blood pressure.
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Li et al. (2024) conducted a meta-analysis in hypertension (n=20,312). Aspirin vs. Placebo or no treatment was evaluated on Systolic blood pressure reduction (MD -0.78, 95% CI -2.41, 0.84). Aspirin did not significantly affect systolic blood pressure (MD -0.78) or diastolic blood pressure (MD -0.86) compared to placebo or no treatment in patients with hypertension.
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