February 1, 1994Journal of Cardiovascular Pharmacology

Effects of Acetylsalicylic Acid on Peripheral Hemodynamics in Patients with Chronic Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors

View Full Paper

Ask AI

Bookmark

Why the study?

Does a single dose of acetylsalicylic acid alter the hemodynamic effects of captopril in patients with chronic heart failure?

Structured PICO

Does a single dose of acetylsalicylic acid alter the hemodynamic effects of captopril in patients with chronic heart failure?

Population

13 patients with congestive heart failure (NYHA class II-IV) receiving maintenance treatment with an ACE inhibitor.

Intervention

Single dose of 25 mg captopril combined with 236 mg acetylsalicylic acid (ASA)

Comparator

Single dose of 25 mg captopril combined with placebo

Outcome

Peripheral blood flow (measured by venous occlusion plethysmography of the calves) and liver blood flow (estimated from indocyanine green clearance)surrogate

A single antithrombotic dose of acetylsalicylic acid does not adversely affect the acute hemodynamic effects of captopril in patients with chronic heart failure.

Authors

JWJan van WijngaardenDeventer Ziekenhuis ASA. J. SmitErasmus MC Cancer Institute PGP. A. de GraeffUniversity Medical Center Groningen

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

ASA with captopril preserves acute hemodynamics in chronic HF; supports safe co-administration and challenges prostaglandin-dependent ACEI mechanism assumptions.

Cite This Study

Wijngaarden et al. (1994) studied this question.

synapsesocial.com/papers/6a73083091c366bb2031e5e2 https://doi.org/10.1097/00005344-199402000-00010

Topics

Heart failure HFrEF treatment

View Full Paper

Ask AI

Bookmark

Implication

ASA with captopril preserves acute hemodynamics in chronic HF; supports safe co-administration and challenges prostaglandin-dependent ACEI mechanism assumptions.