Key result
Cumulative smoking and depressive symptoms over 25 years synergistically increased the odds of higher-risk coronary artery calcification (OR 6.25; 95% CI 3.31-11.83 for 30-packyears and CES-D 16).
Why the study?
Are cumulative smoking exposure and depressive symptoms synergistically associated with coronary artery calcification in young adults over 25 years?
Population
3,189 adults from the Coronary Artery Risk Development in Young Adults study, baseline age 18-30 years…
Design
Cohort
Follow-up
25 years
Authors
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May warrant joint monitoring of smoking and depressive symptoms for CAC risk; hypothesis-generating and requires prospective validation.
Cohort (n=3,189)
Are cumulative smoking exposure and depressive symptoms synergistically associated with coronary artery calcification in young adults over 25 years?
Odds Ratio: 6.25 (95% CI 3.31–11.83)
p-value: p=<.05
Cumulative smoking exposure and depressive symptoms over 25 years have a synergistic association with the development of higher-risk coronary artery calcification.
Carroll et al. (2016) conducted a cohort in Subclinical heart disease (n=3,189). Cumulative smoking exposure and depressive symptoms vs. Lower or no exposure was evaluated on Higher-risk coronary artery calcification (score ≥100) compared with no CAC (score = 0) at Year 25 (OR 6.25, 95% CI 3.31-11.83, p=<.05). Cumulative smoking and depressive symptoms over 25 years synergistically increased the odds of higher-risk coronary artery calcification (OR 6.25; 95% CI 3.31-11.83 for 30-packyears and CES-D 16).
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