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October 1, 1970Proceedings of the National Academy of SciencesOpen Access

Absence of a Cell Membrane Alteration Function in Non-transforming Mutants of Polyoma Virus

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Population

Normal mouse cells (3T3 cells) and polyoma-transformed mouse cells

Comparison

Infection by wild type polyoma virus or… vs Uninfected cells or cells infected with…

Design

Preclinical

Follow-up

up to 36 hours

Authors

TBThomas L. BenjaminUniversity of Hawaiʻi at MānoaMBMax M. BurgerInstitute of Medical Microbiology and Hygiene

Discussion

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Implication

Hypothesis-generating for membrane changes in polyoma transformation; leaves open causal role in vivo.

Structured PICO

P
Population
Normal mouse cells (3T3 cells) and polyoma-transformed mouse cells
I
Intervention
Infection by wild type polyoma virus or non-transforming mutants (NG-18, NG-23, HA-33, NG-59) at a multiplicity of 5-10 pfu/cell
C
Comparator
Uninfected cells or cells infected with non-transforming mutants
O
Outcome
Cell agglutinability (exposure of surface receptor for wheat germ agglutinin and concanavalin A) measured 24-34 hours post-infectionsurrogate

Lytic infection of normal mouse cells by wild type polyoma virus, but not by non-transforming mutants, exposes a cell surface agglutinin receptor, suggesting this membrane alteration is linked to viral transformation.

Cite This Study

Benjamin et al. (1970) studied this question.

synapsesocial.com/papers/6a7315e485ade00e526a5df7https://doi.org/10.1073/pnas.67.2.929
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