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November 1, 1992British Journal of PharmacologyOpen Access

Characterization of two new ETB selective radioligands, 125I‐BQ3020 and 125I‐Ala1,3,11,15ET‐1 in human heart

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Population

Tissue sections of human right atrium and left ventricle

Design

Preclinical

Authors

PMPeter MolenaarElectrophysiologyRKRhoda E. KucSkolkovo Institute of Science and TechnologyADAnthony P. DavenportVascular Medicine

Discussion

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Implication

Offers no immediate clinical utility; extends tools for ET receptor mapping in human myocardium.

Structured PICO

P
Population
Tissue sections of human right atrium and left ventricle
I
Intervention
[125I]-BQ3020 and [125I]-[Ala1,3,11,15]ET-1 radioligands
O
Outcome
Binding affinity (KD) and receptor selectivitysurrogate

The study characterizes two new radioligands as selective for ETB receptors and demonstrates the 76:24% distribution of ETA to ETB receptors in the human left ventricle.

Cite This Study

Molenaar et al. (1992) studied this question.

synapsesocial.com/papers/6a7316d27115af03a3c22ea1https://doi.org/10.1111/j.1476-5381.1992.tb14498.x
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Autoradiographical Localization of Binding Sites for Porcine [125I]Endothelin-1 in Humans, Pigs, and Rats1989 · 182 citations
  2. 2Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy1990 · 646 citations