December 1, 1994British Journal of PharmacologyOpen Access

[¹²⁵I]‐PD151242: a selective ligand for endothelin ETA receptors in human kidney which localizes to renal vasculature

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Population

Human kidney tissue from 5 individuals

Design

Preclinical

Authors

ADAnthony P. DavenportVascular Medicine RKRhoda E. KucAddenbrooke's Hospital SHSarah L. HoskinsUniversity of Cambridge

Discussion

Member takes

Implication

Validates [125I]-PD151242 for ETA mapping in kidney; leaves open translation to human vascular disease.

Structured PICO

Population

Human kidney tissue from 5 individuals

Intervention

[125I]-PD151242 (linear tetrapeptide radioligand)

Outcome

Binding affinity (KD), receptor density (Bmax), and localization of ETA receptorssurrogate

The study demonstrates that [125I]-PD151242 is a selective ligand for ETA receptors in the human kidney, which are primarily localized to the renal vasculature.

Cite This Study

Davenport et al. (1994) studied this question.

synapsesocial.com/papers/6a83089fa250d11ff44cd065 https://doi.org/10.1111/j.1476-5381.1994.tb17140.x

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[¹²⁵I]‐PD151242: a selective ligand for endothelin ETA receptors in human kidney which localizes to renal vasculature

Discussion

Member takes

Implication

Structured PICO

Cite This Study

[¹²⁵I]‐PD151242: a selective ligand for endothelin ETA receptors in human kidney which localizes to renal vasculature

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider