Why the study?
Does cilazapril improve diastolic left ventricular filling pattern and cardiac hypertrophy in patients with mild to moderate essential hypertension?
Does cilazapril improve diastolic left ventricular filling pattern and cardiac hypertrophy in patients with mild to moderate essential hypertension?
Cilazapril treatment for up to 1 year significantly reduces left ventricular hypertrophy and improves diastolic filling in patients with mild to moderate essential hypertension.
May support cilazapril for LV remodeling in hypertension; leaves open need for RCTs before practice change.
The aim of this study was to assess the behavior of the diastolic left ventricular (LV) filling pattern and cardiac hypertrophy after treatment with cilazapril. Twelve patients (9 male and 3 female) with mild to moderate essential hypertension, aged 46 +/- 14.1 years, were treated with cilazapril for 1 year. They underwent Doppler echocardiography at the beginning (I), after 6 months (II), and after 1 year (III) of treatment. The following parameters were evaluated: mean arterial pressure (MAP) automatically recorded for 24 h, interventricular septal and posterior wall thickness, LV and end-diastolic diameter, LV mass index, early (E) and late (A) diastolic filling flow velocities, and the ratio E/A. A significant reduction in LV hypertrophy and an improved diastolic filling pattern of the left ventricle was shown after 6 months of therapy with cilazapril; this improvement still remained after 1 year of therapy.
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Haberbosch et al. (1991) studied this question.
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