Describes a foundational light transmission method to study the kinetics of platelet aggregation, demonstrating the effects of temperature, stirring, ADP, and platelet concentration.
May inform optimized platelet assay conditions in research; leaves open translation to human physiology or practice.
The light transmitted through a suspension of platelets increases if the platelets aggregate. A method derived from this observation has been used to study the kinetics of platelet aggregation. Aggregation is more rapid at 37 degrees C., with rapid stirring, with high concentrations of adenosine diphosphate, and a high platelet concentration; a decrease in any of these conditions slows the process.
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A 1962 study studied this question.
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