Key result
EEL meter detects spontaneous platelet aggregation in ~8% of individuals, linked to increased mechanical fragility.
Observational
The EEL aggregation meter's vertical stirrer subjects platelets to greater mechanical force, revealing spontaneous aggregation in 8% of individuals, likely related to increased mechanical fragility and low plasma ADP-inhibitor levels.
May indicate EEL meter artifact from mechanical stress; leaves open clinical relevance and need for in vivo validation.
During studies on platelet aggregation using the EEL platelet aggregation meter, 8% of the individuals tested were found to have platelets which aggregated spontaneously when citrated, platelet-rich plasma was stirred at 37 degrees C. The EEL aggregation meter differs from other machines in that it incorporates a vertical stirrer which subjects platelets to greater mechanical force. When using this machine it is suggested that spontaneous platelet aggregation is related to increased mechanical fragility of the platelets and low levels of plasma ADP-inhibitor.
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Friedlander et al. (1971) reported an observational. EEL platelet aggregation meter vs. other machines was evaluated on spontaneous platelet aggregation. Testing with the EEL platelet aggregation meter revealed spontaneous platelet aggregation in 8% of individuals, likely due to increased mechanical fragility and low plasma ADP-inhibitor levels.
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