Key result
Mean shear stress was significantly higher in the common carotid artery (1.15 Pa) than in the brachial artery (0.48 Pa; P<0.001), demonstrating that shear stress depends on vascular territory.
Observational (n=10)
Absolute Event Rate: 1.15% vs 0.48%
p-value: p=<0.001
This study demonstrates that shear stress is not constant throughout the vascular system, with significant differences observed between the common carotid and brachial arteries in vivo.
Shear stress heterogeneity warrants site-specific caution in assessments; leaves open whether territory-specific values refine endothelial research.
Shear stress (SS) is thought to be constant throughout the vascular system. Evidence for this supposition is scarce, however. To verify this hypothesis in vivo, we assessed common carotid (CCA) and brachial artery (BA) peak and mean wall shear rate (SR) noninvasively in 10 healthy volunteers (23.7 +/- 3.4 yr) with an ultrasound SR estimation system. SS was estimated from SR and calculated whole blood viscosity. SR was higher (P < 0.05) in the CCA (mean: 359 +/- 111 s(-1); peak: 1,047 +/- 345 s(-1)) than in the BA (mean: 95 +/- 24 s(-1); peak: 770 +/- 170 s(-1)). Whole blood viscosity was higher in the BA than in the CCA (5.1 +/- 0.7 vs. 3.3 +/- 0.6 mPa. s; P < 0.001). Peak SS did not differ between the CCA and the BA, whereas mean SS was significantly higher in the CCA (1.15 +/- 0.21 Pa) than in the BA (0.48 +/- 0.15 Pa; P < 0.001). These results demonstrate that BA SS strongly deviates from CCA SS in vivo.
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Dammers et al. (2003) conducted an observational in Healthy volunteers (n=10). Common carotid artery (CCA) vs. Brachial artery (BA) was evaluated on Mean shear stress (SS) (p=<0.001). Mean shear stress was significantly higher in the common carotid artery (1.15 Pa) than in the brachial artery (0.48 Pa; P<0.001), demonstrating that shear stress depends on vascular territory.
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