Key result
Cardiac imaging using a clinical 1.5T MRI scanner correlated well with histological infarct areas (r=0.807, P<0.001) in a murine ischemia/reperfusion model.
Why the study?
Can clinical 1.5 T MRI scanners accurately assess infarct size and cardiac function in a murine ischemia/reperfusion model?
Can clinical 1.5 T MRI scanners accurately assess infarct size and cardiac function in a murine ischemia/reperfusion model?
Effect estimate: r = 0.807
p-value: p=< .001
Clinical 1.5 T MRI scanners can be feasibly used for basic cardiac phenotyping, including infarct sizing and functional assessment, in murine models.
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Supports feasibility of clinical 1.5T MRI for murine cardiac phenotyping; leaves open translation to other models or species.
Voelkl et al. (2010) studied Murine ischemia/reperfusion. Clinical 1.5T MRI scanner vs. Histology and echocardiography was evaluated on Correlation of MRI-determined infarct sizes with histological infarct areas (r = 0.807, p=< .001). Cardiac imaging using a clinical 1.5T MRI scanner correlated well with histological infarct areas (r=0.807, P<0.001) in a murine ischemia/reperfusion model.
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