Key result
Plasma IL-8 concentrations after an oral glucose load were significantly higher in obese subjects with impaired glucose tolerance compared to normoglycemic weight-matched individuals (6.30 vs 5.02 pg/ml).
Why the study?
Does impaired glucose tolerance affect plasma IL-8 concentrations in obese subjects after a glucose load?
Observational (n=44)
No
Does impaired glucose tolerance affect plasma IL-8 concentrations in obese subjects after a glucose load?
Obese subjects with impaired glucose tolerance exhibit exaggerated increases in atherogenic IL-8 levels following an oral glucose load compared to normoglycemic obese individuals, potentially contributing to accelerated atherogenesis.
May link post-load inflammation to atherogenesis in obese IGT; hypothesis-generating and should not yet change practice.
BACKGROUND: Interleukin 8 (IL-8) is a cytokine with atherogenic properties. In vitro studies revealed that it is produced and secreted by human adipocytes. We recently reported that plasma IL-8 is increased in obese subjects with normal glucose tolerance (NGT). The aim of the present study was to measure plasma IL-8 concentrations in subjects with impaired glucose tolerance (IGT). METHODS: A total of 44 subjects with marked overweight or obesity (BMI > 27.8 kg/m2), 27 with NGT and 17 with IGT, were recruited for the present study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test (OGTT) and after euglycemic hyperinsulinemic clamp. RESULTS: The studied groups did not differ in fasting IL-8 concentrations. Both OGTT and clamp resulted in a significant increase in plasma IL-8. The change in IL-8 after clamp was similar in both groups. In contrast, after OGTT plasma IL-8 levels (IL-8OGTT) were markedly higher in IGT individuals. In IGT, but not NGT group, IL-8OGTT was positively related to postload glucose and negatively to insulin sensitivity. CONCLUSION: Plasma IL-8 concentrations after glucose load are increased in obese IGT subjects in comparison to normoglycemic weight-matched individuals. Increase in plasma IL-8 might be both insulin-mediated (during clamp) and glucose-mediated (during OGTT).
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Strączkowski et al. (2003) conducted an observational in Obesity with or without impaired glucose tolerance (n=44). Impaired glucose tolerance (IGT) vs. Normal glucose tolerance (NGT) was evaluated on Plasma IL-8 concentration after oral glucose tolerance test (OGTT) (p=0.044). Plasma IL-8 concentrations after an oral glucose load were significantly higher in obese subjects with impaired glucose tolerance compared to normoglycemic weight-matched individuals (6.30 vs 5.02 pg/ml).
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