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December 1, 1991Journal of Cardiac Surgery

Hydrodynamic Function of Second Generation Porcine Bioprosthetic Heart Valves

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Why the study?

Do second-generation porcine bioprosthetic heart valves improve hydrodynamic function compared to first-generation and mechanical valves?

Population

Second generation porcine bioprosthetic heart valves

Comparison

Low- or zero-pressure fixation preparation vs First generation porcine bioprostheses…

Design

Preclinical

Authors

MBM.H. ButterfieldUniversity of LeedsJFJohn FisherBuffalo State UniversityJKJohn N. KearneyL'Alliance Boviteq

Discussion

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Overview

May support second-generation porcine valve selection in models; leaves open clinical translation and practice change.

Structured PICO

Do second-generation porcine bioprosthetic heart valves improve hydrodynamic function compared to first-generation and mechanical valves?

P
Population
Second generation porcine bioprosthetic heart valves (Carpentier-Edwards Supra-Annular, Hancock II, Medtronic Intact)
I
Intervention
Low- or zero-pressure fixation preparation
C
Comparator
First generation porcine bioprostheses, bileaflet, and tilting disc mechanical valves
O
Outcome
Hydrodynamic function and leaflet dynamics (pressure drops, energy losses, leaflet opening synchrony, bending strains)surrogate

Second-generation porcine valves show improved hemodynamics, but 'near zero' pressure fixation is needed to ensure synchronous leaflet opening and reduce bending strains.

Cite This Study

Butterfield et al. (1991) studied this question.

synapsesocial.com/papers/6a7343eefa00d98af85626cahttps://doi.org/10.1111/j.1540-8191.1991.tb00350.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Design of a function test apparatus for prosthetic heart valves. Initial results in the mitral position1986 · 39 citations
  2. 2Severe haemolysis with the St. Jude Medical prosthesis1988 · 13 citations
  3. 3Leaflet geometry and function in porcine bioprostheses1991 · 16 citations
  4. 4Failure and Hydrodynamic Function Testing of Explanted Pericardial and Porcine Bioprosthetic Valves1989 · 12 citations
  5. 5Hydrodynamic function of ten prosthetic heart values in the aortic position1988 · 14 citations