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January 1, 1991European Journal of Cardio-Thoracic Surgery

Leaflet geometry and function in porcine bioprostheses

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Population

Five porcine bioprostheses and a fresh tissue porcine valve

Comparison

High pressure and low pressure fixation and… vs Fresh tissue porcine valve

Design

Preclinical

Authors

MBM.H. ButterfieldJFJohn FisherGDG.A. Davies

Discussion

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Overview

Mounting strains may accelerate bioprosthetic degeneration; leaves open clinical durability impact pending human studies.

Structured PICO

P
Population
Five porcine bioprostheses (two high pressure fixed valves: Carpentier Edwards and Hancock; two low pressure fixed valves: Carpentier Edwards Supra-Annular and Hancock 2) and a fresh tissue porcine valve
I
Intervention
High pressure and low pressure fixation and mounting
C
Comparator
Fresh tissue porcine valve
O
Outcome
Leaflet geometry and hydrodynamic function (bending strains)surrogate

Fixation and mounting of porcine bioprostheses alter leaflet geometry and increase bending strains, which may contribute to structural valve degeneration and calcification.

Cite This Study

Butterfield et al. (1991) studied this question.

synapsesocial.com/papers/6a7343eefa00d98af85626cbhttps://doi.org/10.1016/1010-7940(91)90079-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hydrodynamic Function of Second Generation Porcine Bioprosthetic Heart Valves1991 · 18 citations
  2. 2Leaflet stress quantification of porcine vs bovine surgical bioprostheses: an <i>in vitro</i> study2021 · 7 citations
  3. 3A Model of the Geometrical Changes in Aortic Valve Leaflets in Response to Leaflet Extension and Variable Boundary Conditions1992 · 6 citations
  4. 4Stress analysis of porcine bioprosthetic heart valves <i>in vivo</i>1982 · 55 citations
  5. 5<i>IN SILICO</i> MODELING OF PORCINE PERICARDIAL TISSUE LEAFLETS FOR TRANSCATHETER MITRAL VALVE REPLACEMENT2023