Key result
The age- and sex-standardised prevalence of chronic kidney disease was higher in the Russian population sample compared to the Norwegian sample, with an.50.
Why the study?
Little data exists on the prevalence of CKD in the Russian population.
Cross-Sectional (n=22,253)
Yes
The higher prevalence of chronic kidney disease in the Russian population compared to Norway is partially explained by differences in established risk factors, particularly hypertension and its management.
Answers are grounded in this paper and cite their sources.
Higher CKD prevalence in Russian vs Norwegian adults was associated with hypertension; leaves open need for targeted risk-factor studies before practice change.
BACKGROUND: Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD. METHODS: CKD-EPI creatinine equation), albuminuria and or a composite indicator of CKD (one measure of either reduced eGFR or albuminuria) between participants aged 40-69 in the population-based Know Your Heart (KYH) study, Russia (2015-2018 N = 4607) and the seventh Tromsø Study (Tromsø7), Norway (2015-2016 N = 17,646). We assessed the contribution of established CKD risk factors (low education, diabetes, hypertension, antihypertensive use, smoking, obesity) to between-study differences using logistic regression. RESULTS: Prevalence of reduced eGFR or albuminuria was 6.5% (95% Confidence Interval (CI) 5.4, 7.7) in KYH and 4.6% (95% CI 4.0, 5.2) in Tromsø7 standardised for sex and age. Odds of both clinical outcomes were higher in KYH than Tromsø7 (reduced eGFR OR 2.06 95% CI 1.67, 2.54; albuminuria OR 1.54 95% CI 1.16, 2.03) adjusted for sex and age. Risk factor adjustment explained the observed between-study difference in albuminuria (OR 0.92 95% CI 0.68, 1.25) but only partially reduced eGFR (OR 1.42 95% CI 1.11, 1.82). The strongest explanatory factors for the between-study difference was higher use of antihypertensives (Russian sample) for reduced eGFR and mean diastolic blood pressure for albuminuria. CONCLUSIONS: We found evidence of a higher burden of CKD within the sample from the population in Arkhangelsk and Novosibirsk compared to Tromsø, partly explained by between-study population differences in established risk factors. In particular hypertension defined by medication use was an important factor associated with the higher CKD prevalence in the Russian sample.
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Cook et al. (2022) conducted a cross-sectional in Chronic kidney disease (n=22,253). Russian population (Know Your Heart study) vs. Norwegian population (Tromsø7 study) was evaluated on Composite indicator of CKD (reduced eGFR or albuminuria) (OR 1.50, 95% CI 1.21, 1.86). The age- and sex-standardised prevalence of chronic kidney disease was higher in the Russian population sample compared to the Norwegian sample, with an.50.
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