Epinephrine facilitates neurogenic vasoconstriction in humans.
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Why the study?
Does intraarterial epinephrine facilitate neurogenic vasoconstriction in normal human volunteers?
Population
23 normal male volunteers, aged 19-28 yr (mean 22.4). Excluded illness, hypertension, or use of medication.
Comparison
Intraarterial infusion of epinephrine or… vs Baseline responses before infusion and responses…
Design
Other
Follow-up
30 minutes post-infusion
Authors
Discussion
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Implication
May enhance neurogenic vasoconstriction via co-transmitter release in humans; leaves open clinical relevance in cardiovascular disease.
Structured PICO
Does intraarterial epinephrine facilitate neurogenic vasoconstriction in normal human volunteers?
P
Population
23 normal male volunteers, aged 19-28 yr (mean 22.4). Excluded illness, hypertension, or use of medication.
I
Intervention
Intraarterial infusion of epinephrine (50 ng/min) or isoproterenol (10 or 25 ng/min) into a brachial artery for 40 minutes.
C
Comparator
Baseline responses before infusion (during 5% dextrose infusion) and responses 30 minutes after cessation of infusion.
O
Outcome
Ratio of forearm vasoconstrictor responses to lower body negative pressure (LBNP) versus intraarterial norepinephrine (NE), measured via forearm vascular resistance (FVR) in resistance units (RU).surrogate
Epinephrine, but not isoproterenol, facilitates neurogenic vasoconstriction in humans, supporting the concept that epinephrine is taken up by adrenergic terminals and released as a co-transmitter.
Cite This Study
Floras et al. (1988) studied this question.
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