Population
Normotensive and chronically hypertensive (renal encapsulation for 3-5 weeks) rabbits
Comparison
Isoflurane anesthesia at 1.0, 1.5, 2.0, and 2.5%… vs Conscious state (awake) and normotensive controls
Design
Preclinical
Authors
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Isoflurane may blunt baroreflex control irrespective of hypertension; leaves open human translation and clinical relevance.
In a rabbit model, isoflurane anesthesia attenuates baroreflex function equally in both normotensive and chronically hypertensive states.
Bell et al. (1995) studied this question.
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