Why the study?
Does chronic experimental AngII-based hypertension alter the HR baroreflex response to hypoxia or hypercapnia in rabbits?
Population
13 rabbits (7 in the intervention group, 6 as time controls)
Comparison
Continuous 7-week infusion of angiotensin II vs Time controls and baseline measurements before…
Design
Preclinical
Follow-up
7 weeks
Authors
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AngII hypertension spares chemoreflex effects on baroreflex gain in rabbits; leaves open genetic predisposition versus pressure per se in other models.
Does chronic experimental AngII-based hypertension alter the HR baroreflex response to hypoxia or hypercapnia in rabbits?
Chronic experimental AngII-based hypertension does not alter the HR baroreflex response to hypoxia or hypercapnia, suggesting that altered responses seen in other studies may be due to genetic predisposition rather than raised arterial pressure.
Groom et al. (1997) studied this question.
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