Key result
Plasma total calcium concentration was directly correlated with systolic (r=0.25) and diastolic (r=0.22) blood pressure (P<0.001) and independently associated with systemic vascular resistance.
Why the study?
Evidence on the relation between plasma calcium concentration and blood pressure is inconsistent, largely relies on office measurements in populations taking cardiovascular drugs, and often lacks optimal confounder adjustment.
Is plasma total calcium concentration associated with blood pressure and systemic vascular resistance in normotensive and never-treated hypertensive subjects?
Population
618 normotensive or never-treated hypertensive subjects aged 19-72 years without comorbidities or cardiovascular medications
Comparison
Plasma total calcium concentration levels
Design
Cross-sectional study
Authors
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No practice change from cross-sectional data; leaves open calcium's causal role in vascular resistance or hypertension.
Cross-Sectional (n=618)
Is plasma total calcium concentration associated with blood pressure and systemic vascular resistance in normotensive and never-treated hypertensive subjects?
Effect estimate: r = 0.25 (systolic BP) and r = 0.22 (diastolic BP)
p-value: p=<0.001
Higher plasma calcium concentration is independently associated with higher blood pressure and systemic vascular resistance in individuals without cardiovascular disease or medications, suggesting a potential role in primary hypertension.
Oinonen et al. (2019) conducted a cross-sectional in Normotension or never-treated hypertension (n=618). Plasma total calcium concentration was evaluated on Systolic and diastolic blood pressure and systemic vascular resistance (r = 0.25 (systolic BP) and r = 0.22 (diastolic BP), p=<0.001). Plasma total calcium concentration was directly correlated with systolic (r=0.25) and diastolic (r=0.22) blood pressure (P<0.001) and independently associated with systemic vascular resistance.
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