Population
Isolated perfused hearts from normal and diabetic rats
Comparison
Increased heart work and/or addition of insulin… vs Hearts without increased work or normal hearts…
Design
Preclinical
Follow-up
Up to 60 minutes
Authors
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Highlights work-induced metabolic shifts in isolated hearts; leaves open translation to human cardiac energetics or ischemia.
Increased heart work in perfused rat hearts alters glycolysis regulation mediated by changes in tissue contents of adenine nucleotides and citrate, independent of insulin's action on glucose transport.
Opie et al. (1971) studied this question.
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