What question did this study set out to answer?

Determine whether the hypotensive effects of captopril and saralasin in spontaneously hypertensive rats depend on renal mechanisms, circulating renin, or bradykinin potentiation.

March 1, 1980HypertensionOpen Access

Hypotensive action of captopril and saralasin in intact and anephric spontaneously hypertensive rats.

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Why the study?

Does captopril or saralasin reduce blood pressure in intact and anephric spontaneously hypertensive rats?

Population

Anesthetized, spontaneously hypertensive rats and normotensive Wistar-Kyoto rats

Comparison

Intravenous injection of captopril or infusion… vs Injection of vehicle alone

Design

Preclinical

Follow-up

3 hours

Authors

JHJ. S. HutchinsonAugusta University FMF. A. O. MendelsohnCourtauld Institute of Art ADA. E. DoyleVictor Chang Cardiac Research Institute

Discussion

Member takes

Implication

Supports local angiotensin II in SHR hypertension; hypothesis-generating and leaves open human translation.

Key Points

Determine whether the hypotensive effects of captopril and saralasin in spontaneously hypertensive rats depend on renal mechanisms, circulating renin, or bradykinin potentiation.
Administered intravenous captopril (2 mg/kg) or saralasin infusion (10 µg/kg/min) to anesthetized intact and bilaterally nephrectomized spontaneously hypertensive rats (SHR).
Monitored blood pressure continuously for three hours and measured plasma renin activity, using vehicle-treated SHR and normotensive Wistar-Kyoto (NT-WK) rats as controls.
Captopril produced an indistinguishable, progressive blood pressure drop over three hours in both intact and nephrectomized SHR, despite plasma renin activity falling to <30% of baseline in nephrectomized animals.
Saralasin infusion caused equivalent blood pressure reductions in intact and anephric SHR, whereas captopril induced no significant blood pressure changes in intact or anephric normotensive controls.

Structured PICO

Does captopril or saralasin reduce blood pressure in intact and anephric spontaneously hypertensive rats?

Population

Anesthetized, spontaneously hypertensive rats (SHR) (intact and bilaterally nephrectomized) and normotensive Wistar-Kyoto (NT-WK) rats

Intervention

Intravenous injection of captopril (2 mg/kg) or infusion of saralasin (10 micrograms/kg/min)

Comparator

Injection of vehicle alone

Outcome

Blood pressure reduction over a 3-hour periodsurrogate

Captopril and saralasin lower blood pressure in spontaneously hypertensive rats independently of the kidneys or circulating renin, suggesting a role for locally produced angiotensin II.

Cite This Study

Hutchinson et al. (1980) studied this question.

synapsesocial.com/papers/6a735a78668da3c6682c29cd https://doi.org/10.1161/01.hyp.2.2.119

Topics

Hypertension management

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Hypotensive action of captopril and saralasin in intact and anephric spontaneously hypertensive rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Hypotensive action of captopril and saralasin in intact and anephric spontaneously hypertensive rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider