Inhibition of Converting Enzyme of the Renin-Angiotensin System in Kidneys and Hindlegs of Dogs
Key result
Conversion of angiotensin I to angiotensin II was 40% in the hindleg compared to only 2.1% in the kidney of anesthetized dogs.
Population
Anesthetized dogs
Comparison
Intra-arterial injections of angiotensin I or… vs Responses without enzyme inhibitor, and…
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Should not alter ACE inhibitor use; leaves open local vascular conversion's role in human hypertension.
Structured PICO
P
Population
Anesthetized dogs used to compare angiotensin-converting enzyme activity in hindlegs and kidneys.
I
Intervention
Intra-arterial injections of angiotensin I or angiotensin II, and an inhibitor of angiotensin-converting enzyme
C
Comparator
Responses without enzyme inhibitor, and comparison between hindleg and kidney vascular beds
O
Outcome
Angiotensin-converting enzyme activity (conversion of angiotensin I to angiotensin II) and changes in blood flowsurrogate
Main Result
Absolute Event Rate: 40% vs 2.1%
Angiotensin-converting enzyme activity is significantly greater in the hindleg vascular bed compared to the kidney in dogs.
Cite This Study
Aiken et al. (1972) studied Anesthetized dogs. Angiotensin I and Angiotensin II vs. Hindleg vs Kidney vascular beds was evaluated on Conversion of angiotensin I to angiotensin II. Conversion of angiotensin I to angiotensin II was 40% in the hindleg compared to only 2.1% in the kidney of anesthetized dogs.