January 1, 2002Hypertension ResearchOpen Access

Difference in Coronary Blood Flow Dynamics between Patients with Hypertension and Those with Hypertrophic Cardiomyopathy.

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Why the study?

Does the phasic pattern of coronary blood flow differ between patients with hypertensive left ventricular hypertrophy and those with hypertrophic cardiomyopathy?

Population

32 subjects with normal coronary arteriograms, including 12 patients with hypertensive left ventricular…

Comparison

Measurement of coronary blood flow velocity… vs Control subjects with normal coronary…

Design

Cross-sectional

Authors

KMKatsushi MisawaOsaka University of Human Sciences YNYutaka NittaKanazawa University TMTakao MatsubaraKanazawa University

Discussion

Member takes

Implication

Coronary flow velocity ratio may aid differentiation of hypertensive LVH from HCM; hypothesis-generating and requires prospective validation before clinical use.

Structured PICO

Does the phasic pattern of coronary blood flow differ between patients with hypertensive left ventricular hypertrophy and those with hypertrophic cardiomyopathy?

Population

32 subjects with normal coronary arteriograms, including 12 patients with hypertensive left ventricular hypertrophy (LVH) (mean age 57.8, 7 men/5 women), 10 patients with hypertrophic cardiomyopathy (HCM) (mean age 59.9, 7 men/3 women), and 10 control subjects (mean age 51.0, 7 men/3 women). Exclusions: obstructive type of HCM, diabetes mellitus.

Intervention

Measurement of coronary blood flow (CBF) velocity using a Doppler guidewire at rest and after serial intracoronary infusions of acetylcholine (10^-8, 10^-7, and 10^-6 mol/l) and a bolus injection of 10 mg papaverine.

Comparator

Control subjects with normal coronary arteriograms and no hypertension, diabetes mellitus, or hypercholesterolemia. Also compared hypertensive LVH directly against HCM.

Outcome

Coronary blood flow (CBF) dynamics, including baseline CBF, coronary flow reserve (after papaverine), endothelium-dependent vasodilatation (after acetylcholine), and diastolic/systolic velocity ratio.surrogate

The diastolic/systolic coronary blood flow velocity ratio differs significantly between hypertensive LVH and HCM, offering a potential non-invasive diagnostic tool to differentiate the two conditions.

Limitations

Echocardiography was used to estimate left ventricular mass instead of MRI or CT, which may be better since disproportionate LVH is common in HCM
Small sample size
Myocardial mass indexes were significantly different between patients with hypertensive LVH and those with HCM

Cite This Study

Misawa et al. (2002) studied this question.

synapsesocial.com/papers/6a735d2a0d609fee3b6c2fe8 https://doi.org/10.1291/hypres.25.711

Topics

Hypertrophic cardiomyopathy Hypertension management Echocardiography

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Implication

Coronary flow velocity ratio may aid differentiation of hypertensive LVH from HCM; hypothesis-generating and requires prospective validation before clinical use.

Difference in Coronary Blood Flow Dynamics between Patients with Hypertension and Those with Hypertrophic Cardiomyopathy.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Difference in Coronary Blood Flow Dynamics between Patients with Hypertension and Those with Hypertrophic Cardiomyopathy.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider