Why the study?
Does chronic heart failure alter skeletal muscle fiber type composition, size, capillary density, or beta-adrenergic receptor density in a dog model?
Population
17 dogs with chronic heart failure produced by sequential intracoronary microembolizations, and 9 control…
Comparison
Chronic heart failure model vs Control dogs (n=9)
Design
Preclinical
Authors
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HF fiber-type shift in dogs is hypothesis-generating; leaves open relevance to human myopathy or exercise intolerance.
Does chronic heart failure alter skeletal muscle fiber type composition, size, capillary density, or beta-adrenergic receptor density in a dog model?
Chronic heart failure in a canine model induces a shift in skeletal muscle fiber composition from slow-twitch type I to fast-twitch type II fibers without altering capillary density or beta-adrenergic receptor density.
Sabbah et al. (1993) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: