Why the study?
Does aortic stenosis-induced cardiac hypertrophy and heart failure cause changes in myosin heavy chain expression and atrophy in rat skeletal muscle?
Does aortic stenosis-induced cardiac hypertrophy and heart failure cause changes in myosin heavy chain expression and atrophy in rat skeletal muscle?
Skeletal muscle phenotype changes, including MHC shifts and atrophy, occur during late cardiac hypertrophy prior to overt heart failure symptoms in a rat model.
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Should not inform clinical HF management; hypothesis-generating for MHC shifts as early markers in cardiac disease models.
Carvalho et al. (2003) studied this question.
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