Why the study?
Does formalinized heterograft of calf or pig origin prevent re-operation in patients requiring mitral or tricuspid valve replacement?
Does formalinized heterograft of calf or pig origin prevent re-operation in patients requiring mitral or tricuspid valve replacement?
Formalinized heterografts of calf or pig origin are unsatisfactory for mitral valve replacement due to early cusp disruption requiring re-operation.
Answers are grounded in this paper and cite their sources.
May warrant avoiding formalinized heterografts for mitral replacement; leaves open durability questions for alternatives.
On review of six patients who had mitral valve replacement by formalinized heterografts of calf or pig origin, and of one patient who had tricuspid valve replacement by calf heterograft, it is our conclusion that such prostheses, mounted as we have employed them, are unsatisfactory. All such mitral valve replacements have required re-operation within 16 months because of cusp disruption. None has demonstrated thromboembolic complications. In all cases studied, cusps demonstrated complete acellularity. In the restricted stress situation of tricuspid valve replacement, it would appear that the function of heterografts may be extended.
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Wright et al. (1971) studied this question.
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