Why the study?
The study was conducted to evaluate the relationship of gamma glutamyl transferase, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio with nondipper hypertension.
Are elevated levels of GGT, NLR, and PLR associated with a nondipper blood pressure pattern in prehypertensive and hypertensive patients?
Are elevated levels of GGT, NLR, and PLR associated with a nondipper blood pressure pattern in prehypertensive and hypertensive patients?
Easily accessible biomarkers including PLR, NLR, and GGT are independently associated with nondipper hypertension in both prehypertensive and hypertensive patients.
PLR and NLR elevations may mark nondipper hypertension; hypothesis-generating for risk stratification, prospective studies needed.
Aim: The aim of this study was to evaluate the relation of gamma glutamyl transferase (GGT), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with nondipper hypertension. Methods: This study included a total of 409 patients. Patients were grouped into hypertension, prehypertension and normotensive groups, according to their clinical blood pressure. All patients were also followed by ambulatory blood pressure. Results: Mean PLR and NLR were higher in the nondippers compared with dippers among both prehypertensive and hypertensive patients. In addition, PLR (OR: 1.011; 95% CI: 1004–1017; p = 0.001), NLR (OR: 2.296, 95% CI: 1634–3225; p < 0.001), and GGT (OR: 1.067; 95% CI: 1042–1092; p < 0.001) were found to be associated with nondipper pattern among whole study population. Conclusion: The PLR, NLR and GGT values are easily accessible and fairly useful, independently associated with nondipper hypertension for both hypertensive and prehypertensive patients.
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Bozduman et al. (2019) studied this question.
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