Key result
Higher serum uric acid levels were a significant determinant of a nondipper blood pressure pattern among hypertensive patients (OR 2.69; 95% CI 1.60-4.52; p=0.000).
Observational (n=432)
Odds Ratio: 2.69 (95% CI 1.6–4.52)
p-value: p=0.000
Higher serum uric acid and mean platelet volume, along with lower platelet-to-lymphocyte ratio and serum albumin, are significant determinants of a nondipper blood pressure pattern in hypertensive patients.
May link higher uric acid to nondipper hypertension; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: The aim of this study was to evaluate serum uric acid levels, inflammatory markers [C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR)] and mean platelet volume (MPV) among hypertensive patients with or without chronic kidney disease (CKD) with respect to dipping status. METHODS: A total of 432 hypertensive patients with (n = 340) or without (n = 92) CKD who had ambulatory blood pressure monitoring recordings were included. Correlation of serum uric acid levels with inflammatory markers (CRP, PLR, NLR) was evaluated as was the logistic regression analysis for determinants of nondipper pattern. RESULTS: Nondipper pattern was noted in 65.2% and 79.7% of non-CKD and CKD patients, respectively. Multivariate logistic regression analysis revealed that only serum uric acid (OR, 2.69; 95% CI, 1.60 to 4.52; p = 0.000), MPV (OR, 1.81; 95% CI, 1.30 to 2.53; p = 0.000), PLR (OR, 0.98; 95% CI, 0.97 to 0.99; p = 0.000), and serum albumin (OR, 0.42; 95% CI, 0.19 to 0.93; p = 0.031) were significant determinants of nondipper pattern in the overall study population. CONCLUSION: In conclusion, our findings revealed higher prevalence of nondipper pattern in hypertensive patients with than without CKD and significantly higher levels for uric acid, CRP, MPV, PLR, and NLR among nondipper than dipper hypertensive patients with CKD. High levels for uric acid and MPV and lower levels for PLR and serum albumin were noted as significant determinants of nondipper pattern among hypertensive patients.
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Ahbap et al. (2016) conducted an observational in Hypertension with or without chronic kidney disease (n=432). Serum uric acid levels was evaluated on Nondipper blood pressure pattern (OR 2.69, 95% CI 1.60 to 4.52, p=0.000). Higher serum uric acid levels were a significant determinant of a nondipper blood pressure pattern among hypertensive patients (OR 2.69; 95% CI 1.60-4.52; p=0.000).
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