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January 1, 2013World Journal of NephrologyOpen Access

Pericytes synthesize renin

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Why the study?

Does angiotensinogen deficiency increase renin expression in renal interstitial pericytes in mice?

Population

Wild type and angiotensinogen deficient mice at different developmental stages from embryonic day 18 to…

Comparison

Angiotensinogen deficiency (AGT -/-) vs Wild type (WT) mice

Design

Preclinical

Follow-up

Up to postnatal day 70

Authors

ABAlison BergSydney Children’s Hospitals Network

Discussion

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Implication

Indicates compensatory pericyte renin upregulation in AGT deficiency; hypothesis-generating for RAS biology, no clinical implications yet.

Structured PICO

Does angiotensinogen deficiency increase renin expression in renal interstitial pericytes in mice?

P
Population
Wild type (WT) and angiotensinogen deficient (AGT -/-) mice at different developmental stages from embryonic day 18 (E18) to postnatal day 70 (P70) (n=64)
I
Intervention
Angiotensinogen deficiency (AGT -/-)
C
Comparator
Wild type (WT) mice
O
Outcome
Number of pericytes positive for renin per area of 0.32 mm(2) (density)surrogate

Interstitial pericytes synthesize renin during development, and this expression increases significantly in response to angiotensinogen deficiency.

Cite This Study

Alison Berg (2013) studied this question.

synapsesocial.com/papers/6a7395ad30bc69be694e694fhttps://doi.org/10.5527/wjn.v2.i1.11
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin and angiotensinogen gene expression in maturing rat kidney1988 · 111 citations
  2. 2Distribution of renin mRNA and its protein in the developing kidney1989 · 216 citations
  3. 3Genetic control of blood pressure and the angiotensinogen locus.1995 · 643 citations
  4. 4Ablation of renin-expressing juxtaglomerular cells results in a distinct kidney phenotype2004 · 64 citations
  5. 5Renin-expressing cells are associated with branching of the developing kidney vasculature.1998 · 97 citations