What question did this study set out to answer?

To evaluate recurrence-free survival time and identify independent prognostic factors to refine clinical staging for surgically treated soft tissue sarcoma.

January 1, 1986Cancer

Recurrence-free survival time for surgically treated soft tissue sarcoma patients. Multivariate analysis of five prognostic factors

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Authors

HHHerman W. HeiseZimmer Biomet (Netherlands)MMMax H. MyersUniversity of Iowa WRWilliam O. RussellAmerican Cancer Society

Discussion

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Implication

Cohort study reveals tumor location, extension, and size predict recurrence-free survival in soft tissue sarcoma, suggesting staging systems require expansion beyond histologic grade.

Key Points

To evaluate recurrence-free survival time and identify independent prognostic factors to refine clinical staging for surgically treated soft tissue sarcoma.
Evaluated recurrence-free survival outcomes in a cohort of 594 patients selected from 1,215 individuals originally evaluated by the American Joint Committee Task Force on Soft Tissue Sarcoma.
Conducted a multivariate Weibull regression analysis on 297 patients with complete records to evaluate five prognostic variables alongside histologic tumor grade.
Within 5 years, 331 of 594 patients developed a recurrence (100 local only, 123 metastatic only, and 108 both) with a median time to recurrence of 9.7 months.
Recurrence was strongly associated with mortality within 5 years, resulting in 245 deaths among the 331 recurrent patients compared to 31 deaths among the 263 non-recurrent patients.
Multivariate analysis showed direct tumor extension, symptoms, and tumor location significantly predicted time to any recurrence, while tumor size significantly predicted metastatic recurrence.

Cite This Study

Heise et al. (1986) studied this question.

synapsesocial.com/papers/6a73a7631c100ebba7fb6beb https://doi.org/10.1002/1097-0142(19860101)57:1<172::aid-cncr2820570133>3.0.co;2-d

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January 1, 1986Cancer

Recurrence-free survival time for surgically treated soft tissue sarcoma patients. Multivariate analysis of five prognostic factors

View Full Paper

Ask AI

Bookmark

Authors

HHHerman W. HeiseZimmer Biomet (Netherlands)MMMax H. MyersUniversity of Iowa WRWilliam O. RussellAmerican Cancer Society

Discussion

Member takes

Implication

Cohort study reveals tumor location, extension, and size predict recurrence-free survival in soft tissue sarcoma, suggesting staging systems require expansion beyond histologic grade.

Key Points

To evaluate recurrence-free survival time and identify independent prognostic factors to refine clinical staging for surgically treated soft tissue sarcoma.
Evaluated recurrence-free survival outcomes in a cohort of 594 patients selected from 1,215 individuals originally evaluated by the American Joint Committee Task Force on Soft Tissue Sarcoma.
Conducted a multivariate Weibull regression analysis on 297 patients with complete records to evaluate five prognostic variables alongside histologic tumor grade.
Within 5 years, 331 of 594 patients developed a recurrence (100 local only, 123 metastatic only, and 108 both) with a median time to recurrence of 9.7 months.
Recurrence was strongly associated with mortality within 5 years, resulting in 245 deaths among the 331 recurrent patients compared to 31 deaths among the 263 non-recurrent patients.
Multivariate analysis showed direct tumor extension, symptoms, and tumor location significantly predicted time to any recurrence, while tumor size significantly predicted metastatic recurrence.

Cite This Study

Heise et al. (1986) studied this question.

synapsesocial.com/papers/6a73a7631c100ebba7fb6beb https://doi.org/10.1002/1097-0142(19860101)57:1<172::aid-cncr2820570133>3.0.co;2-d

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