Contributions of cardiac “funny” (f) channels and sarcoplasmic reticulum Ca2+in regulating beating rate of mouse and guinea pig sinoatrial node
Population
Mouse and guinea pig atrial/sinoatrial node preparations
Comparison
Selective block of cardiac "funny" channels… vs Baseline/unblocked state
Design
Preclinical
Authors
Discussion
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Member takes
Implication
I(f) and SR contributions to mouse atrial rate warrant caution in human extrapolation; leaves open pacemaker mechanisms in sinus node disease.
Structured PICO
P
Population
Mouse and guinea pig atrial/sinoatrial node preparations
I
Intervention
Selective block of cardiac "funny" (f) channels (ZD7288, ivabradine) and/or suppression of sarcoplasmic reticulum (SR) function (ryanodine, cyclopiazonic acid) in the absence and presence of β-adrenoceptor stimulation (isoprenaline)
C
Comparator
Baseline/unblocked state
O
Outcome
Spontaneous beating ratesurrogate
Sarcoplasmic reticulum-derived Ca2+ plays a role in regulating I(f) and the beating rate of sinoatrial node preparations, with additional contributions to β-adrenoceptor stimulation effects independent of I(f).
Cite This Study
Nazarov et al. (2015) studied this question.