Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 2002Anesthesia & Analgesia

The incidence of hypotension was significantly lower in the patients who received phenylephrine 1.5 or 3 mg than in the controls, both in the normotensive and hypertensive groups (P < 0.01).

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does prophylactic IM phenylephrine reduce the incidence of spinal anesthesia-induced hypotension in elderly patients undergoing hip fracture surgery?

Population

90 normotensive and hypertensive patients aged >65 yr undergoing surgery for hip fracture

Comparison

Prophylactic IM phenylephrine at doses of 1.5 mg… vs Saline IM (placebo)

Design

RCT, randomized, double-blinded, placebo-controlled

Authors

KNKohki NishikawaMYMichiaki YamakageKOKeiichi Omote

Discussion

Loading...

Member takes

Overview

Supports prophylactic IM phenylephrine in elderly hip fracture surgery under spinal anesthesia; extends RCT evidence to this high-risk population.

Structured PICO

Does prophylactic IM phenylephrine reduce the incidence of spinal anesthesia-induced hypotension in elderly patients undergoing hip fracture surgery?

P
Population
90 normotensive and hypertensive patients aged >65 yr undergoing surgery for hip fracture
I
Intervention
Prophylactic IM phenylephrine at doses of 1.5 mg or 3 mg
C
Comparator
Saline IM (placebo)
O
Outcome
Incidence of hypotension (>25% decrease in mean arterial blood pressure [MAP] from baseline)surrogate

Prophylactic IM injection of 1.5 mg phenylephrine safely and effectively reduces the incidence of hypotension associated with spinal anesthesia in elderly patients undergoing hip fracture surgery.

Cite This Study

Nishikawa et al. (2002) studied this question.

synapsesocial.com/papers/6a73bf71d0d1650e4d69f08ehttps://doi.org/10.1213/00000539-200209000-00040
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prophylactic IM Small-Dose Phenylephrine Blunts Spinal Anesthesia-Induced Hypotensive Response During Surgical Repair of Hip Fracture in the Elderly2002 · 18 citations
  2. 2Comparing prophylactic effect of phenylephrine and ephedrine on hypotension during spinal anesthesia for hip fracture surgery2016 · 13 citations
  3. 3Comparison of the effect of different doses of phenylephrine infusion on the prevention of hypotension in the elderly under spinal anaesthesia in orthopaedic surgery2024
  4. 4A Comparative Study of Infusion of Ephedrine and Phenylephrine on Hemodynamic Stability After Spinal Anesthesia in Elderly Patients Undergoing Lower Limb Orthopedic Surgeries2024 · 4 citations
  5. 5Hemodynamic effects of norepinephrine versus phenylephrine infusion for prophylaxis against spinal anesthesia-induced hypotension in the elderly population undergoing hip fracture surgery: a randomized controlled trial2020 · 16 citations