Why the study?
Does prophylactic phenylephrine prevent hypotension better than ephedrine in patients undergoing hip fracture surgery with spinal anesthesia?
Population
92 patients aged 40-70 years, ASA class I and II, undergoing hip fracture surgery with spinal anesthesia
Comparison
Phenylephrine 50 μg IV bolus immediately before… vs Ephedrine 10 mg IV bolus immediately before…
Design
RCT, Randomized (syringes randomly taken out from a box), Double-blind
Follow-up
30 minutes after spinal anesthesia
Key result
Prophylactic intravenous phenylephrine significantly reduced the need for additional vasopressors (8.7% vs 23.9%, p=0.04) compared to ephedrine during spinal anesthesia for hip fracture surgery.
Authors
Loading...
Supports phenylephrine preference over ephedrine for prophylaxis; extends RCT evidence to hip fracture surgery under spinal anesthesia.
RCT (n=92)
Double-blind
randomized
No
Does prophylactic phenylephrine prevent hypotension better than ephedrine in patients undergoing hip fracture surgery with spinal anesthesia?
Absolute Event Rate: 8.7% vs 23.9%
p-value: p=0.04
Prophylactic IV phenylephrine (50 μg) is more effective than ephedrine (10 mg) in preventing hypotension during spinal anesthesia for hip fracture surgery.
Abbasivash et al. (2016) conducted an RCT in Hip fracture requiring surgery under spinal anesthesia (n=92). Phenylephrine vs. Ephedrine 10 mg IV bolus was evaluated on Requirement for additional vasopressor (p=0.04). Prophylactic intravenous phenylephrine significantly reduced the need for additional vasopressors (8.7% vs 23.9%, p=0.04) compared to ephedrine during spinal anesthesia for hip fracture surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: