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September 1, 2002Anesthesia & Analgesia

Prophylactic IM Small-Dose Phenylephrine Blunts Spinal Anesthesia-Induced Hypotensive Response During Surgical Repair of Hip Fracture in the Elderly

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Why the study?

Does prophylactic IM phenylephrine reduce spinal anesthesia-induced hypotension in elderly patients undergoing hip fracture surgery?

Population

90 normotensive and hypertensive patients aged >65 years undergoing surgery for hip fracture under…

Comparison

Prophylactic intramuscular phenylephrine at… vs Intramuscular saline (placebo)

Design

RCT, randomized, double-blinded, placebo-controlled

Authors

KNKohki NishikawaMYMichiaki YamakageKOKeiichi Omote

Discussion

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Overview

Prophylactic IM phenylephrine reduces spinal hypotension in elderly hip fracture surgery; supports routine use and extends evidence to normotensive and hypertensive patients.

Structured PICO

Does prophylactic IM phenylephrine reduce spinal anesthesia-induced hypotension in elderly patients undergoing hip fracture surgery?

P
Population
90 normotensive and hypertensive patients aged >65 years undergoing surgery for hip fracture under hyperbaric tetracaine spinal anesthesia
I
Intervention
Prophylactic intramuscular (IM) phenylephrine at doses of 1.5 mg or 3 mg
C
Comparator
Intramuscular saline (placebo)
O
Outcome
Incidence of hypotension (>25% decrease in mean arterial blood pressure [MAP] from baseline)surrogate

Prophylactic IM injection of 1.5 mg phenylephrine safely and effectively reduces the incidence of spinal anesthesia-induced hypotension in elderly patients undergoing hip fracture surgery.

Cite This Study

Nishikawa et al. (2002) studied this question.

synapsesocial.com/papers/6a73bf71d0d1650e4d69f08dhttps://doi.org/10.1097/00000539-200209000-00040
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prophylactic IM Small-Dose Phenylephrine Blunts Spinal Anesthesia-Induced Hypotensive Response During Surgical Repair of Hip Fracture in the Elderly2002 · 17 citations
  2. 2Comparison of the effect of different doses of phenylephrine infusion on the prevention of hypotension in the elderly under spinal anaesthesia in orthopaedic surgery2024
  3. 3Comparing prophylactic effect of phenylephrine and ephedrine on hypotension during spinal anesthesia for hip fracture surgery2016 · 13 citations
  4. 4A Comparative Study of Infusion of Ephedrine and Phenylephrine on Hemodynamic Stability After Spinal Anesthesia in Elderly Patients Undergoing Lower Limb Orthopedic Surgeries2024 · 4 citations
  5. 5Hemodynamic effects of norepinephrine versus phenylephrine infusion for prophylaxis against spinal anesthesia-induced hypotension in the elderly population undergoing hip fracture surgery: a randomized controlled trial2020 · 16 citations