Cardiac hypertrophy depends upon sleep blood pressure

Hypertensive rats (hypertension induced by application of a 0.20 mm clip to the left renal artery)

Intermittent blood pressure reduction using captopril (75 mg/kg/day or 25 mg/kg/day in drinking water between 1800 and 2000 h, or 15 mg/kg/day or 5 mg/kg/day intra-peritoneally at 0800 h)

Different doses and timings of captopril administration

Cardiac hypertrophy (cardiac index measured by weighing ventricles factored by body weight)surrogate