February 15, 2011CirculationOpen Access

Comparison of the Structure of the Aortic Valve and Ascending Aorta in Adults Having Aortic Valve Replacement for Aortic Stenosis Versus for Pure Aortic Regurgitation and Resection of the Ascending Aorta for Aneurysm

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Why the study?

Does pure aortic regurgitation compared to aortic stenosis predict greater ascending aortic medial elastic fiber loss in patients with ascending aortic aneurysms?

Population

122 adult patients with ascending aortic aneurysm undergoing aortic valve replacement and resection of the…

Comparison

Pure aortic regurgitation (AR) vs Aortic stenosis (AS)

Design

Cross-sectional

Authors

WRWilliam C. RobertsGeneral Cardiology TVTravis J. VowelsHouston Methodist JKJong Mi KoJohns Hopkins University

Discussion

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Implication

AR may signal higher wall vulnerability warranting surveillance; leaves open whether thresholds for replacement should differ by valve lesion.

Structured PICO

Does pure aortic regurgitation compared to aortic stenosis predict greater ascending aortic medial elastic fiber loss in patients with ascending aortic aneurysms?

Population

122 adult patients with ascending aortic aneurysm (unassociated with aortitis or acute dissection) undergoing aortic valve replacement and resection of the ascending aorta.

Intervention

Pure aortic regurgitation (AR)

Comparator

Aortic stenosis (AS)

Outcome

Ascending aortic medial elastic fiber loss (EFL) graded 0 to 4+surrogate

Patients with pure aortic regurgitation and ascending aortic aneurysms have significantly greater medial elastic fiber loss compared to those with aortic stenosis, suggesting a higher structural risk that may favor concurrent aortic replacement.

Cite This Study

Roberts et al. (2011) studied this question.

synapsesocial.com/papers/6a73de07bbad068246a8bfa9 https://doi.org/10.1161/circulationaha.110.972406

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Implication

AR may signal higher wall vulnerability warranting surveillance; leaves open whether thresholds for replacement should differ by valve lesion.

Comparison of the Structure of the Aortic Valve and Ascending Aorta in Adults Having Aortic Valve Replacement for Aortic Stenosis Versus for Pure Aortic Regurgitation and Resection of the Ascending Aorta for Aneurysm

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of the Structure of the Aortic Valve and Ascending Aorta in Adults Having Aortic Valve Replacement for Aortic Stenosis Versus for Pure Aortic Regurgitation and Resection of the Ascending Aorta for Aneurysm

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider