Key result
Patients undergoing isolated aortic valve replacement for aortic stenosis in 1991-2004 were older and had lighter valves with lower pressure gradients compared to those treated in 1961-1990.
Why the study?
How have the clinical and pathological characteristics of patients undergoing isolated aortic valve replacement for aortic stenosis changed between 1961-1990 and 1991-2004?
Population
1849 patients having isolated aortic valve replacement for aortic valve stenosis from 3 different medical…
Comparison
Aortic valve replacement during the fourth and… vs Aortic valve replacement during the first 3…
Design
Cohort
Authors
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Shifts toward older patients with milder aortic stenosis warrant cautious era comparisons; leaves open updated natural history and referral pattern studies.
Observational (n=1,849)
Yes
How have the clinical and pathological characteristics of patients undergoing isolated aortic valve replacement for aortic stenosis changed between 1961-1990 and 1991-2004?
Over time, patients undergoing aortic valve replacement for aortic stenosis have become older with less severe stenosis and lighter valves, although congenitally malformed valves remain the most common etiology.
Roberts et al. (2005) conducted an observational in Aortic Valve Stenosis (n=1,849). Aortic valve replacement during 1991-2004 vs. Aortic valve replacement during 1961-1990 was evaluated on Aortic valve structure, valve weight, age at operation, preoperative transvalvular peak pressure gradient, calculated aortic valve area, and simultaneous CABG. Patients undergoing isolated aortic valve replacement for aortic stenosis in 1991-2004 were older and had lighter valves with lower pressure gradients compared to those treated in 1961-1990.
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