Electrocardiographic Left Ventricular Hypertrophy Is Independently Associated With Better Long-Term Outcomes in Dilated Cardiomyopathy Patients

Shouji Matsushima; Hidetaka Kaku; Nobuyuki Enzan; Tomomi Ide; Taiki Higo; Miyuki Tsuchihashi‐Makaya; Hiroyuki Tsutsui

doi:10.1253/circrep.cr-19-0025

May 29, 2019Circulation ReportsOpen Access

Electrocardiographic Left Ventricular Hypertrophy Is Independently Associated With Better Long-Term Outcomes in Dilated Cardiomyopathy Patients

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Why the study?

Electrocardiographic left ventricular hypertrophy is observed in patients with dilated cardiomyopathy, but its prognostic importance is unclear.

Does the presence of electrocardiographic left ventricular hypertrophy predict better long-term outcomes in patients with dilated cardiomyopathy?

Structured PICO

Does the presence of electrocardiographic left ventricular hypertrophy predict better long-term outcomes in patients with dilated cardiomyopathy?

P

Population

261 patients with dilated cardiomyopathy (DCM) hospitalized for worsening heart failure (HF) from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD), mean age 62.6, 72.7% male. Key inclusion: dilated LV (end-diastolic diameter >55 mm) and reduced ejection fraction <50% in the absence of specific cardiac or systemic diseases.

I

Intervention

Presence of electrocardiographic left ventricular hypertrophy (ECG-LVH) assessed using the Sokolow-Lyon voltage criteria

C

Comparator

Absence of electrocardiographic left ventricular hypertrophy (no ECG-LVH)

O

Outcome

All-cause death and the composite of death or HF hospitalization during ≥1 year of follow-upcomposite

Limitations

JCARE-CARD is a prospective cohort registry and, despite covariate adjustment, other measured and unmeasured factors might have influenced outcomes.
Possibility of misdiagnosis in a prospective observational cohort study.
Multicollinearity between ECG-LVH and blood pressure.
Only the Sokolow-Lyon voltage criteria were used for evaluation of ECG-LVH status, and the numerical value of the QRS amplitude in each lead and other ECG findings were not collected.

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Implication

Electrocardiographic left ventricular hypertrophy is an independent predictor of better long-term outcomes, including lower mortality and rehospitalization, in patients with dilated cardiomyopathy.

Abstract

Background:Electrocardiogram (ECG) findings of left ventricular hypertrophy (LVH; ECG-LVH) are observed in patients with dilated cardiomyopathy (DCM), but the prognostic importance is unclear. The present study assessed the impact of QRS voltage on long-term outcomes, including mortality and rehospitalization, in patients with DCM using a database of patients hospitalized for worsening heart failure (HF).

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Cite This Study

Matsushima et al. (2019) studied this question.

synapsesocial.com/papers/6a73e9ac0375516f85f16381 https://doi.org/10.1253/circrep.cr-19-0025

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Electrocardiographic Left Ventricular Hypertrophy Is Independently Associated With Better Long-Term Outcomes in Dilated Cardiomyopathy Patients

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Structured PICO

Limitations

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Implication

Abstract

Discussion

Cite This Study

Electrocardiographic Left Ventricular Hypertrophy Is Independently Associated With Better Long-Term Outcomes in Dilated Cardiomyopathy Patients

Figures

Structured PICO

Limitations

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Implication

Abstract

Discussion

Cite This Study

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