Why the study?
Does pathogenesis-based management with intravenous immunoglobulin and milrinone reduce mortality in children with severe EV71 infections?
Does pathogenesis-based management with intravenous immunoglobulin and milrinone reduce mortality in children with severe EV71 infections?
Management with intravenous immunoglobulin and milrinone may reduce mortality in children with severe EV71 infections complicated by pulmonary edema.
May support IVIG-milrinone use in severe EV71; leaves open confirmation by randomized trials before practice change.
Enterovirus 71 (EV71) has emerged as a significant cause of brainstem encephalitis and acute flaccid paralysis in Taiwan. It may be complicated by autonomic nervous system dysregulation and pulmonary edema (PE). Cytokines in the central nervous system and systemic inflammatory responses play important roles in the pathogenesis of EV71-associated PE. Pathogenesis-based management with intravenous immunoglobulin and milrinone has been associated with reduced mortality in children with severe EV71 infections.
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Wang et al. (2008) studied this question.
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