December 24, 2009Journal of Pineal Research

Melatonin interactions with blood pressure and vascular function during l-NAME-induced hypertension

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Why the study?

Does melatonin reduce blood pressure and improve vascular function in rats with L-NAME-induced hypertension?

Structured PICO

Does melatonin reduce blood pressure and improve vascular function in rats with L-NAME-induced hypertension?

Population

Male adult Wistar rats with L-NAME-induced hypertension

Intervention

Melatonin (10 mg/kg) for 5 weeks

Comparator

Control group, L-NAME (40 mg/kg) alone, and melatonin (10 mg/kg) alone

Outcome

Systolic and diastolic blood pressure, conjugated dienes concentration, NOS RNA expression and activity, and COX-1/COX-2 RNA expressionsurrogate

In L-NAME-induced hypertensive rats, melatonin reduces oxidative load but has limited effects on blood pressure and the nitric oxide pathway.

Discussion

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Implication

Melatonin's antioxidant benefit without meaningful BP reduction cautions against clinical use; leaves open selective vascular pathway research in hypertension.

Cite This Study

Paulis et al. (2009) studied this question.

synapsesocial.com/papers/6a73f6fcc553859489f168dd https://doi.org/10.1111/j.1600-079x.2009.00732.x

Topics

Hypertension management

View Full Paper

Ask AI

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Implication

Melatonin's antioxidant benefit without meaningful BP reduction cautions against clinical use; leaves open selective vascular pathway research in hypertension.

Melatonin interactions with blood pressure and vascular function during l-NAME-induced hypertension

Structured PICO

Discussion

Implication

Cite This Study

Topics

Melatonin interactions with blood pressure and vascular function during l-NAME-induced hypertension

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider