January 1, 1972British Journal of PharmacologyOpen Access

Investigations of the mode of action of a new antidysrhythmic drug, Kö 1173

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Population

Preclinical models: stripped frog sciatic nerve, anaesthetized guinea-pigs with ouabain-induced ventricular…

Comparison

Kö 1173 (1--2-amino-propane), administered… vs Lignocaine; untreated controls.

Design

Preclinical

Authors

BSBramah N. SinghElectrophysiology EWE. M. Vaughan WilliamsHaffkine Institute

Discussion

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Implication

May support antidysrhythmic development in models; leaves open translation to human arrhythmias.

Structured PICO

Population

Preclinical models: stripped frog sciatic nerve, anaesthetized guinea-pigs with ouabain-induced ventricular fibrillation (n=10 for reversion experiment), isolated rabbit atria, and rabbit atrial/ventricular cells.

Intervention

Kö 1173 (1-(2',6'-dimethyl-phenoxy)-2-amino-propane), administered intravenously (mean dose 3.3 mg/kg in guinea pigs) or applied to isolated tissues.

Comparator

Lignocaine (for local anaesthetic potency); untreated controls (for ouabain toxicity).

Outcome

Reversion to sinus rhythm (in guinea pigs), local anaesthetic potency, and electrophysiological parameters (maximum rate of depolarization, resting potential, action potential duration).surrogate

Kö 1173 is a novel antidysrhythmic agent that effectively reverses ouabain-induced ventricular fibrillation and depresses the maximum rate of depolarization in preclinical models.

Cite This Study

Singh et al. (1972) studied this question.

synapsesocial.com/papers/6a7413edd76de32a6a0a4b52 https://doi.org/10.1111/j.1476-5381.1972.tb07232.x

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Investigations of the mode of action of a new antidysrhythmic drug, Kö 1173

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Investigations of the mode of action of a new antidysrhythmic drug, Kö 1173

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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