Why the study?
Does weight loss, reduced sodium intake, or a combination of both lower blood pressure and prevent hypertension in moderately overweight individuals with high-normal diastolic blood pressure?
Population
2,382 middle-aged, moderately overweight individuals with a diastolic blood pressure between 83 and 89 mm…
Comparison
Weight loss, reduced sodium intake, or a… vs Control group (implied by four randomized groups).
Design
RCT, Randomized into four groups
Authors
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Baseline balance supports causal attribution of BP effects to interventions; confirms successful randomization in this overweight cohort.
Does weight loss, reduced sodium intake, or a combination of both lower blood pressure and prevent hypertension in moderately overweight individuals with high-normal diastolic blood pressure?
The TOHP II trial successfully randomized a representative US cohort of moderately overweight individuals with high-normal diastolic BP, with well-balanced baseline characteristics across the four intervention groups.
Appel et al. (1995) studied this question.
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