Why the study?
Does weight loss, sodium reduction, or their combination decrease blood pressure and prevent hypertension in adults with high-normal blood pressure?
Population
2382 participants who are 110 to 165% of desirable body weight, with high-normal DBP and SBP less than 140…
Comparison
Weight loss alone, sodium reduction alone, or… vs Placebo group (using a 2 x 2 factorial design)
Design
RCT, allocated at random to the four treatment arms using a 2 x 2 factorial…
Follow-up
3 to 4 years
Authors
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This paper describes the design of a multicenter randomized trial evaluating the efficacy of weight loss and sodium reduction in preventing hypertension among adults with high-normal blood pressure.
Does weight loss, sodium reduction, or their combination decrease blood pressure and prevent hypertension in adults with high-normal blood pressure?
This paper describes the design of a multicenter randomized trial evaluating the efficacy of weight loss and sodium reduction in preventing hypertension among adults with high-normal blood pressure.
Hebert et al. (1995) studied this question.
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