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August 6, 2026BMC NephrologyOpen Access

The relationship between the rate of decline in residual kidney function and technique failure in patients undergoing peritoneal dialysis: a retrospective cohort study

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Authors

YXYulin XuXLXiaoqin LiuSGShuwang Ge

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Overview

Retrospective cohort study explores the link between residual kidney function decline and technique failure in peritoneal dialysis patients, suggesting important monitoring thresholds.

Key Points

  • This study aims to determine the relationship between the rate of decline in residual kidney function and the risk of technique failure in patients undergoing peritoneal dialysis.
  • Single-centre, retrospective cohort study involving 539 patients
  • Used pre-specified Cox models to analyze RKF decline and technique failure
  • Performed RCS analysis and Kaplan-Meier curves over a median follow-up of 30 months
  • 28.2% of patients experienced technique failure by the end of follow-up
  • Faster RKF decline (HR = 1.19, 95% CI 1.05–1.34, p < 0.001) correlated with higher technique failure risk
  • Identified candidate threshold for RKF decline at -0.20 ml/min/1.73 m2/month with reduced technique failure-free survival (log-rank p = 0.027)

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a74379d764cddc9499d4fa7https://doi.org/10.1186/s12882-026-05210-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Fast Decline of Residual Renal Function in the First Year is a Predictor for Early Withdrawal from Peritoneal Dialysis in Non-Diabetic Patients2019 · 10 citations
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  3. 3Rapid Change in Residual Renal Function Decline is Associated with Lower Survival and Worse Residual Renal Function Preservation in Peritoneal Dialysis Patients2017 · 18 citations
  4. 4Baseline and Time‐Averaged Values Predicting Residual Renal Function Decline Rate in Japanese Peritoneal Dialysis Patients2017 · 11 citations
  5. 5#546 Decline of kidney function before and after start of peritoneal dialysis (PD)2024