Key result
A fast decline of residual renal function in the first year of peritoneal dialysis increased the risk of all-cause mortality and conversion to hemodialysis (HR 2.74; 95% CI 1.53-4.90; P=0.001).
Why the study?
Little is known about the relationship between early residual renal function decline and survival in non-diabetic peritoneal dialysis patients.
Does a fast decline of residual renal function predict all-cause mortality and conversion to hemodialysis in non-diabetic peritoneal dialysis patients?
Population
567 non-diabetic patients starting peritoneal dialysis
Comparison
High RRF decline (>0.308 ml/min/1.73m2/month) vs low RRF decline (≤0.308 ml/min/1.73m2/month)
Design
Cohort study
Follow-up
Median 43 months
Authors
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Early RRF decline monitoring may aid prognostication in non-diabetic PD; leaves open whether preservation strategies improve survival.
Cohort (n=567)
Does a fast decline of residual renal function predict all-cause mortality and conversion to hemodialysis in non-diabetic peritoneal dialysis patients?
Hazard Ratio: 2.74 (95% CI 1.53–4.9)
Absolute Event Rate: 23.2% vs 11%
p-value: p=0.001
A faster decline in residual renal function during the first year of peritoneal dialysis is a strong predictor of all-cause mortality and conversion to hemodialysis in non-diabetic patients.
Wang et al. (2019) conducted a cohort in Non-diabetic peritoneal dialysis (n=567). Fast decline of residual renal function (RRF) in the first year vs. Low RRF decline (≤0.308 ml/min/1.73m2/month) was evaluated on Composite of all-cause mortality and conversion to hemodialysis (HR 2.74, 95% CI 1.53-4.90, p=0.001). A fast decline of residual renal function in the first year of peritoneal dialysis increased the risk of all-cause mortality and conversion to hemodialysis (HR 2.74; 95% CI 1.53-4.90; P=0.001).
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