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November 1, 1994Journal of Clinical InvestigationOpen Access

Mechanism of cAMP regulation of renin gene transcription by proximal promoter.

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Population

Embryonic kidney-derived 293 cells and juxtaglomerular cells

Design

Preclinical

Authors

KTKouichi TamuraGeneral CardiologySUS UmemuraKyoto Prefectural University of MedicineSYSatoshi YamaguchiKagoshima University

Discussion

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Overview

Provides mechanistic insight into renin transcriptional control in models; leaves open relevance to human cardiovascular therapies.

Structured PICO

P
Population
Embryonic kidney-derived 293 cells and juxtaglomerular cells
I
Intervention
cAMP stimulation
O
Outcome
Ren-1C gene transcription and nuclear factor binding to the RP-2 elementsurrogate

The study demonstrates that the RP-2 element in the proximal promoter plays a crucial role in cAMP-mediated regulation of renin gene transcription.

Cite This Study

Tamura et al. (1994) studied this question.

synapsesocial.com/papers/6a744401f40cdade3da7fa92https://doi.org/10.1172/jci117547
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin mRNA quantification using polymerase chain reaction in cultured juxtaglomerular cells. Short-term effects of cAMP on renin mRNA and secretion.1993 · 47 citations
  2. 2Juxtaglomerular cells cultured on a reconstituted basement membrane1992 · 10 citations
  3. 3Lewis K. Dahl Memorial Lecture. The renin system and four lines fo hypertension research. Nephron heterogeneity, the calcium connection, the prorenin vasodilator limb, and plasma renin and heart attack.1992 · 55 citations
  4. 4Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.1986 · 1,425 citations
  5. 5Structure, expression, and regulation of the murine renin genes.1991 · 115 citations