Renal function and mortality following cardiac resynchronization therapy
Key result
Chronic kidney disease was associated with lower 3-year survival compared to normal or mild renal dysfunction in patients undergoing cardiac resynchronization therapy (57% vs 72%, P<0.01).
Why the study?
Does chronic kidney disease reduce survival in patients with congestive heart failure undergoing cardiac resynchronization therapy?
Population
482 patients with congestive heart failure not on dialysis undergoing cardiac resynchronization therapy…
Comparison
Cardiac resynchronization therapy in patients… vs Cardiac resynchronization therapy in patients…
Design
Cohort
Follow-up
3 years
Authors
Discussion
Loading...
Member takes
Implication
CKD identifies higher-risk CRT recipients; leaves open whether renal function should modify device selection in heart failure.
Study Design
Type
Cohort (n=482)
Multicenter
No
Structured PICO
Does chronic kidney disease reduce survival in patients with congestive heart failure undergoing cardiac resynchronization therapy?
P
Population
482 patients not on dialysis undergoing cardiac resynchronization therapy device implantation, evaluated for 3-year survival.
E
Exposure
Cardiac resynchronization therapy in patients with chronic kidney disease (GFR ≤60 mL/min/1.73 m²)
C
Comparator
Cardiac resynchronization therapy in patients with normal or mild renal dysfunction
O
Outcome
Survival/mortality at 3 yearshard clinical
Main Result
Absolute Event Rate: 57% vs 72%
p-value: p=<0.01
Chronic kidney disease is a significant predictor of poor survival following cardiac resynchronization therapy and should be factored into patient selection.
Cite This Study
Lin et al. (2010) conducted a cohort in Heart failure (n=482). Chronic kidney disease vs. Normal or mild renal dysfunction was evaluated on 3-year survival (p=<0.01). Chronic kidney disease was associated with lower 3-year survival compared to normal or mild renal dysfunction in patients undergoing cardiac resynchronization therapy (57% vs 72%, P<0.01).